Structure of PDB 6xet Chain A

Receptor sequence
>6xetA (length=426) Species: 9823 (Sus scrofa) [Search protein sequence]
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPDDSFNTFFSETGA
GKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHY
TIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLS
VDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEA
IYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTN
LVPYPRIHFPLATYAPVISAEKEQLSVAEITNACFEPANQMVKCDPRHGK
YMACCLLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPT
VVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGE
GMEEGEFSEAREDMAALEKDYEEVGV
3D structure
PDB6xet Design, Synthesis, and Biological Evaluation of Stable Colchicine-Binding Site Tubulin Inhibitors 6-Aryl-2-benzoyl-pyridines as Potential Anticancer Agents.
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP A G10 Q11 A12 Q15 D98 A99 N101 S140 G143 G144 T145 G146 E183 N206 Y224 N228 G10 Q11 A12 Q15 D90 A91 N93 S132 G135 G136 T137 G138 E175 N198 Y216 N220
BS02 TU2 A T179 A180 V181 T171 A172 V173
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005200 structural constituent of cytoskeleton
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0007017 microtubule-based process
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0015630 microtubule cytoskeleton

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6xet, PDBe:6xet, PDBj:6xet
PDBsum6xet
PubMed34378386
UniProtQ2XVP4|TBA1B_PIG Tubulin alpha-1B chain (Gene Name=TUBA1B)

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