Structure of PDB 6xeo Chain A

Receptor sequence
>6xeoA (length=1118) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
YRYTLPVKAGEQRLLGELTGAACATLVAEIAERHAGPVVLIAPDMQNALR
LHDEISQFTDQMVMNLADWETLPYDSFSPHQDIISSRLSTLYQLPTMQRG
VLIVPVNTLMQRVCPHSFLHGHALVMKKGQRLSRDALRTQLDSAGYRHVD
QVMEHGEYATRGALLDLFPMGSELPYRLDFFDDEIDSLRVFDVDSQRTLE
EVEAINLLPAHEFPTDKAAIELFRSQWRDTFEVKRDPEHIYQQVSKGTLP
AGIEYWQPLFFSEPLPPLFSYFPANTLLVNTGDLETSAERFQADTLARFE
NRGVDPMRPLLPPQSLWLRVDELFSELKNWPRVQLKTEHLPTKAANANLG
FQKLPDLAVQAQQKAPLDALRKFLETFDGPVVFSVESEGRREALGELLAR
IKIAPQRIMRLDEASDRGRYLMIGAAEHGFVDTVRNLALICESDLLGERI
GQPVVHLEHGVGRYAGMTTLEAGGITGEYLMLTYANDAKLYVPVSSLHLI
SRYAGGAEENAPLHKLGGDAWSRARQKAAEKVRDVAAELLDIYAQRAAKE
GFAFKHDREQYQLFCDSFPFETTPDQAQAINAVLSDMCQPLAMDRLVCGD
VGFGKTEVAMRAAFLAVDNHKQVAVLVPTTLLAQQHYDNFRDRFANWPVR
IEMISRFRSAKEQTQILAEVAEGKIDILIGTHKLLQSDVKFKDLGLLIVD
EEHRFGVRHKERIKAMRANVDILTLTATPIPRTLNMAMSGMRDLSIIATP
PARRLAVKTFVREYDSMVVREAILREILRGGQVYYLYNDVENIQKAAERL
AELVPEARIAIGHGQMRERELERVMNDFHHQRFNVLVCTTIIETGIDIPT
ANTIIIERADHFGLAQLHQLRGRVGRSHHQAYAWLLTPHPKAMTTDAQKR
LEAIASLEDLGAGFALATHDLEIRGAGELLGEEQSGSMETIGFSLYMELL
ENAVDALKAGREPSLEDLTSQQTEVELRMPSLLPDDFIPDVNTRLSFYKR
IASAKTENELEEIKVELIDRFGLLPDPARTLLDIARLRQQAQKLGIRKLE
GNEKGGVIEFAEKNHVNPAWLIGLLQKQPQHYRLDGPTRLKFIQDLSERK
TRIEWVRQFMRELEENAI
3D structure
PDB6xeo Molecular determinants for dsDNA translocation by the transcription-repair coupling and evolvability factor Mfd.
ChainA
Resolution5.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A H711 K712 F734 I870 I871 H682 K683 F705 I841 I842
BS02 dna A R733 F734 R737 R848 D925 R704 F705 R708 R819 D896
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015616 DNA translocase activity
GO:0016787 hydrolase activity
GO:0043175 RNA polymerase core enzyme binding
Biological Process
GO:0000716 transcription-coupled nucleotide-excision repair, DNA damage recognition
GO:0006281 DNA repair
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006294 nucleotide-excision repair, preincision complex assembly
GO:0006355 regulation of DNA-templated transcription
GO:0006974 DNA damage response
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:1990391 DNA repair complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6xeo, PDBe:6xeo, PDBj:6xeo
PDBsum6xeo
PubMed32719356
UniProtP30958|MFD_ECOLI Transcription-repair-coupling factor (Gene Name=mfd)

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