Structure of PDB 6xe6 Chain A

Receptor sequence
>6xe6A (length=826) Species: 9606 (Homo sapiens) [Search protein sequence]
KSYAALIADWPVVVLGMCTMFIVVCALVGVLVPELPDFSDPLLGFEPRGT
AIGQRLVTWNNMVKNTGYKATLANVPSDRYSRVVFLWNLPAIKSMCNVDN
SRIRSHPQFGDCCPSWTLGNYIAILNNRSSCQKIVERDVSHTLKLLRTCA
KHYPRKCTKYNAVYQILHYLVDKDFMTPKTPALKYSMLFSPTEKGESMMN
IYLDNFENWNTGIEFGIKHSLFQDYLLMDTVYPAIAIVIVLLVMCVYTKS
MFITLMTMFAIISSLIVSYFLYRVVFHFEFFPFMNLTALIILVGIGADDA
FVLCDVWNYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYV
SNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVLHERYCQKCHKVLFAIS
EASRIFFEKVLPCIVIKFRYLWLFWFLALTVGGAYIVCINPKMKLPSLEL
SEFQVFRSSHPFERYDAEYKKHHGEELHMPITVIWGVSPEDNGNPLNPKS
KGKLTLDSSFNIASPASQAWILHFCQKLRNQTFFYQTDEQDFTSCFIETF
KQWMENQDCPCCSHWSFPYKQEIFELCIKRAIMEYHLDSKTPGPRFDIND
TIRAVVLEFQSTYLFTLAYEKMHQFYKEVDSWISSELSSAPEGLSNGWFV
SNLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAG
TIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDPDR
EGKVIFSLSRVGSAMAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLIMCI
SWAFATFFFQCMCRCLGPQGTCGQIP
3D structure
PDB6xe6 Structure of human Dispatched-1 provides insights into Hedgehog ligand biogenesis.
ChainA
Resolution4.53 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Y01 A S981 M988 S663 M670
BS02 Y01 A M1098 M1113 C1117 M780 M795 C799
BS03 Y01 A D579 H603 H1055 R1078 A1082 D305 H329 H737 R760 A764
BS04 Y01 A F725 S1026 L1029 L1030 I1118 F426 S708 L711 L712 I800
BS05 Y01 A Q497 T504 L560 L563 Y1105 Q223 T230 L286 L289 Y787
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:6xe6, PDBe:6xe6, PDBj:6xe6
PDBsum6xe6
PubMed32646883
UniProtQ96F81|DISP1_HUMAN Protein dispatched homolog 1 (Gene Name=DISP1)

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