Structure of PDB 6xds Chain A

Receptor sequence
>6xdsA (length=485) Species: 9606,83333 [Search protein sequence]
TEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVA
GDGPDIIFWAHDRFGGYAQSGLLAEITPAAAFQDKLYPFTWDAVRYNGKL
IAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQE
PYFTWPLIAADGGYAFKYAAGKYDIKDVGVDNAGAKAGLTFLVDLIKNKH
MNADTDYSIAEHAFNHGETAMTINGPWAWSNIDTSAVNYGVTVLPTFKGQ
PSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVA
LKSYEEELVKDPRVAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASG
RQTVDAALAAAQTNAHDTTVFQGVAGQSLQVSCPYDSMKHWGRRKAWCRQ
LGEKGPCQRVVSTHLSFLRRWNGSTAITDDTLGGTLTITLRNLQPHDAGL
YQCQSLHGSEADTLRKVLVEVLADPLDHHHHHHHH
3D structure
PDB6xds Development of a robust crystallization platform for immune receptor TREM2 using a crystallization chaperone strategy.
ChainA
Resolution1.466 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLC A D14 K15 E111 Y155 W230 D13 K14 E108 Y152 W227
BS02 GLC A W62 D65 E153 P154 Y155 W340 W59 D62 E150 P151 Y152 W337
BS03 GLC A E44 E45 R66 P154 W340 Y341 R344 E43 E44 R63 P151 W337 Y338 R341
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0015144 carbohydrate transmembrane transporter activity
GO:1901982 maltose binding
Biological Process
GO:0006974 DNA damage response
GO:0008643 carbohydrate transport
GO:0015768 maltose transport
GO:0034219 carbohydrate transmembrane transport
GO:0034289 detection of maltose stimulus
GO:0042956 maltodextrin transmembrane transport
GO:0055085 transmembrane transport
GO:0060326 cell chemotaxis
Cellular Component
GO:0016020 membrane
GO:0030288 outer membrane-bounded periplasmic space
GO:0042597 periplasmic space
GO:0043190 ATP-binding cassette (ABC) transporter complex
GO:0055052 ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
GO:1990060 maltose transport complex

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Cellular Component
External links
PDB RCSB:6xds, PDBe:6xds, PDBj:6xds
PDBsum6xds
PubMed33221505
UniProtP0AEX9|MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE);
Q9NZC2|TREM2_HUMAN Triggering receptor expressed on myeloid cells 2 (Gene Name=TREM2)

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