Structure of PDB 6xd2 Chain A

Receptor sequence
>6xd2A (length=323) Species: 9823 (Sus scrofa) [Search protein sequence]
IGDEPLENYLDTEYFGTIGIGTPAQDFTVIFDTGSSNLWVPSVYCSSLAC
SDHNQFNPDDSSTFEATSQELSITYGTGSMTGILGYDTVQVGGISDTNQI
FGLSETEPGSFLYYAPFDGILGLAYPSISASGATPVFDNLWDQGLVSQDL
FSVYLSSNDDSGSVVLLGGIDSSYYTGSLNWVPVSVEGYWQITLDSITMD
GETIACSGGCQAIVDTGTSLLTGPTSAIANIQSDIGASENSDGEMVISCS
SIDSLPDIVFTINGVQYPLSPSAYILDSCTSGFEGMDVPTSSGELWILGD
VFIRQYYTVFDRANNKVGLAPVA
3D structure
PDB6xd2 Porcine pepsin in complex with darunavir
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D32 S35 N37 W39 Y75 D215 T218
Catalytic site (residue number reindexed from 1) D32 S35 N37 W39 Y75 D215 T218
Enzyme Commision number 3.4.23.1: pepsin A.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 017 A D32 G34 Y75 G76 T77 F111 Y189 D215 G217 V291 D32 G34 Y75 G76 T77 F111 Y189 D215 G217 V288
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6xd2, PDBe:6xd2, PDBj:6xd2
PDBsum6xd2
PubMed
UniProtP00791|PEPA_PIG Pepsin A (Gene Name=PGA)

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