Structure of PDB 6xcf Chain A

Receptor sequence
>6xcfA (length=417) Species: 1491 (Clostridium botulinum) [Search protein sequence]
MQFVNKQFNYKDPVNGVDIAYIKIPNVGQMQPVKAFKIHNKIWVIPERDT
FTNPEEGDLNPPPPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGR
MLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIG
PSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTN
PLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAYYEMSG
LEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVG
TTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFV
KFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQN
TEINNMNFTKLKNFTGL
3D structure
PDB6xcf Catch and Anchor Approach To Combat Both Toxicity and Longevity of Botulinum Toxin A.
ChainA
Resolution1.68 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.69: bontoxilysin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UZP A I161 Q162 F163 F192 F194 H223 E224 H227 E262 Y366 D370 V373 I156 Q157 F158 F187 F189 H218 E219 H222 E257 Y361 D365 V368
BS02 ZN A H223 H227 E262 H218 H222 E257
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6xcf, PDBe:6xcf, PDBj:6xcf
PDBsum6xcf
PubMed32886509
UniProtP0DPI0|BXA1_CLOBO Botulinum neurotoxin type A (Gene Name=botA)

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