Structure of PDB 6xcb Chain A

Receptor sequence
>6xcbA (length=414) Species: 1491 (Clostridium botulinum) [Search protein sequence]
QFVNKQFNYKDPVNGVDIAYIKIPNVQMQPVKAFKIHNKIWVIPERDTFT
NPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTD
LGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQSYRSEELNLVIIG
PSADIIQFECKSFGLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLL
GAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEV
SFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTA
SLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFF
KVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEI
NNMNFTKLKNFTGL
3D structure
PDB6xcb Catch and Anchor Approach To Combat Both Toxicity and Longevity of Botulinum Toxin A.
ChainA
Resolution1.74 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.69: bontoxilysin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H223 H227 E262 H215 H219 E254
BS02 UZY A F163 E164 C165 H223 E224 H227 E262 Y366 F158 E159 C160 H215 E216 H219 E254 Y358
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6xcb, PDBe:6xcb, PDBj:6xcb
PDBsum6xcb
PubMed32886509
UniProtP0DPI0|BXA1_CLOBO Botulinum neurotoxin type A (Gene Name=botA)

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