Structure of PDB 6xaf Chain A

Receptor sequence
>6xafA (length=172) Species: 9606 (Homo sapiens) [Search protein sequence]
MKLMIVGNTGSGKTTLLQQLMKQSATVGIDVKDWPIQIRDKRKRDLVLNV
WDFAGHEEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARA
SSSPVILVGTHLDVSDEAQRAACMSKITKELLNKRGFPAIRDYHFVNATE
ESDALAKLRKTIINESLNFKIR
3D structure
PDB6xaf Structural basis for conformational plasticity in the GTPase domain of the Parkinson's disease-associated protein LRRK2
ChainA
Resolution1.968 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP A G1344 S1345 G1346 K1347 T1348 T1349 H1453 D1455 N1489 A1490 T1491 G10 S11 G12 K13 T14 T15 H111 D113 N147 A148 T149
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:6xaf, PDBe:6xaf, PDBj:6xaf
PDBsum6xaf
PubMed
UniProtQ5S007|LRRK2_HUMAN Leucine-rich repeat serine/threonine-protein kinase 2 (Gene Name=LRRK2)

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