Structure of PDB 6xa3 Chain A

Receptor sequence
>6xa3A (length=409) Species: 529089 (Streptomyces sp. 307-9) [Search protein sequence]
YDIPTTENLYFQGSEFVPMLQDSVPLELDDAFMQDPHSVYARLNAEGSAH
RVMMPPGPVCGGLPVWLITGYEEVRSALADPRLSTDLNRFSSALATHMLH
SDPPDHTRLRKLVNKAFTSRAIEKLRPEIEQITGELLAALPDEDPVDLLD
AFAFPLPIRVICLLLGVPLEEQENFKSWSKALVSGDSPAATAAASTAMIE
YLGDLIERKRRTPTDDVLAALVSARDVDDRLTETELVSMAFLLFIGGHET
TVNTLGNGTLHLMRNLDQWEALRQDRSLLPGAVEEFLRLESPLKHATFRC
ATEDLRIGDTAIPAGDFVLLALASANRDPERFGDPHTLDVRRPTGGHVAF
GHGIHYCLGAPLARMEAQVAFGVLLDTFPAMRLAVDPEDMRWRTSTLIRG
LHSLPVRLN
3D structure
PDB6xa3 Molecular Basis of Iterative C─H Oxidation by TamI, a Multifunctional P450 monooxygenase from the Tirandamycin Biosynthetic Pathway.
ChainA
Resolution2.96 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) S186 E251 T252 C359 L360 G361
Catalytic site (residue number reindexed from 1) S184 E249 T250 C357 L358 G359
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM A M100 H108 R112 L245 G248 G249 T252 T253 T256 P294 L295 A298 T299 R301 A351 F352 G353 H357 C359 G361 A365 M98 H106 R110 L243 G246 G247 T250 T251 T254 P292 L293 A296 T297 R299 A349 F350 G351 H355 C357 G359 A363
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:6xa3, PDBe:6xa3, PDBj:6xa3
PDBsum6xa3
PubMed33569241
UniProtD3Y1J3

[Back to BioLiP]