Structure of PDB 6x8h Chain A

Receptor sequence
>6x8hA (length=152) Species: 9606 (Homo sapiens) [Search protein sequence]
DKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTT
TFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGI
IYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVE
TD
3D structure
PDB6x8h Caspase-8 in complex with AOMK inhibitor, Ac-DW3-KE, forms tetrahedral adduct
ChainA
Resolution1.48 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.22.61: caspase-8.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R258 N261 R36 N39
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6x8h, PDBe:6x8h, PDBj:6x8h
PDBsum6x8h
PubMed
UniProtQ14790|CASP8_HUMAN Caspase-8 (Gene Name=CASP8)

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