Structure of PDB 6x8e Chain A

Receptor sequence
>6x8eA (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
QFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHL
RDFEREIEILKSLQHDNIVKYKGVCYSRRNLKLIMEYLPYGSLRDYLQKH
KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGD
FGLTKVLPQDKEYYKVKSPIFWYAPESLTESKFSVASDVWSFGVVLYELF
TYIEKSKSPPAEFMRMIIVTHLIELLKNNGRLPRPDGCPDEIYMIMTECW
NNNVNQRPSFRDLALRVDQIRDNM
3D structure
PDB6x8e Discovery of Tyrosine Kinase 2 (TYK2) Inhibitor (PF-06826647) for the Treatment of Autoimmune Diseases.
ChainA
Resolution1.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D976 A978 R980 N981 D994
Catalytic site (residue number reindexed from 1) D132 A134 R136 N137 D150
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UWP A L855 K857 G861 S862 V863 K882 Y931 L932 P933 G935 R980 N981 L983 G993 D994 L13 K15 G19 S20 V21 K40 Y87 L88 P89 G91 R136 N137 L139 G149 D150 MOAD: ic50=65nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6x8e, PDBe:6x8e, PDBj:6x8e
PDBsum6x8e
PubMed32787094
UniProtO60674|JAK2_HUMAN Tyrosine-protein kinase JAK2 (Gene Name=JAK2)

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