Structure of PDB 6x72 Chain A

Receptor sequence

>6x72A (length=438) Species: 4932 (Saccharomyces cerevisiae)

IVACDDPDFLTSYFAHSRLHHLSAWKANLKDKFLNENIHKYTKITDKDTY
IIFHIDFDCFFATVAYLCRSSSFSACDFKRDPIVVCHGTKNSDIASCNYV
ARSYGIKNGMWVSQAEKMLPNGIKLISLPYTFEQFQLKSEAFYSTLKRLN
IFNLILPISIDEAVCVRIIPDNIHNTNTLNARLCEEIRQEIFQGTNGCTV
SIGCSDSLVLARLALKMAKPNGYNITFKSNLSEEFWSSFKLDDLPGVGHS
TLSRLESTFDSPHSLNDLRKRYTLDALKASVGSKLGMKIHLALQGQDDEE
SLKILYDPKEVLQRKSLSIDINWGIRFKNITQVDLFIERGCQYLLEKLNE
INKTTSQITLKLMRRCKDAPIEPPKYMGMGRCDSFSRSSRLGIPTNEFGI
IATEMKSLYRTLGCPPMELRGLALQFNKLVDVGPDNNQ

3D structure

• PDB: 6x72 Visualizing Rev1 catalyze protein-template DNA synthesis.
• Chain: A
• Resolution: 2.19 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	R324 F367 A401 S402 D467 E468 G552 G554 H555 S556 T557 Q663 S692 R693 S694 R696	R18 F61 A95 S96 D161 E162 G246 G248 H249 S250 T251 Q357 S386 R387 S388 R390
BS02	dna	A	Y319 F320 H322 S323 R324 L325 H326 S329 H393 G394 T395 K396 N397 S398 D399 K590 R620 K621 S624 I625 D626 N628 W629 K681 Y682 G684 M685 G686	Y13 F14 H16 S17 R18 L19 H20 S23 H87 G88 T89 K90 N91 S92 D93 K284 R314 K315 S318 I319 D320 N322 W323 K375 Y376 G378 M379 G380
BS03	PO4	A	C365 Y405 R408 K525	C59 Y99 R102 K219
BS04	PO4	A	C365 S402 R408 N414	C59 S96 R102 N108
BS05	MG	A	D548 V553	D242 V247

Gene Ontology

Molecular Function

• GO:0003684 damaged DNA binding
• GO:0003887 DNA-directed DNA polymerase activity

Biological Process

• GO:0006281 DNA repair

External links

• PDB: RCSB:6x72, PDBe:6x72, PDBj:6x72
• PDBsum: 6x72
• PubMed: 32999062
• UniProt: P12689|REV1_YEAST DNA repair protein REV1 (Gene Name=REV1)