Structure of PDB 6x5p Chain A

Receptor sequence
>6x5pA (length=232) Species: 9606 (Homo sapiens) [Search protein sequence]
VVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVEVKITVV
AGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLN
SYVTPICIADKEYTNIFLKFGSGYVSGWGRVFHKGASALVLQYLRVPLVD
RATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLTGI
ISWGEECAMKGKYGIYTKVSRYVNWIKEKTKL
3D structure
PDB6x5p Discovery of hydroxy pyrimidine Factor IXa inhibitors.
ChainA
Resolution1.997 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H56 D104 Q197 G198 D199 S200 G201
Catalytic site (residue number reindexed from 1) H41 D87 Q180 G181 D182 S183 G184
Enzyme Commision number 3.4.21.22: coagulation factor IXa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UQD A H56 D194 S195 C196 Q197 S200 S219 W220 G221 E222 C224 H41 D177 S178 C179 Q180 S183 S202 W203 G204 E205 C207 MOAD: ic50=30nM
BindingDB: IC50=30nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6x5p, PDBe:6x5p, PDBj:6x5p
PDBsum6x5p
PubMed32527459
UniProtP00740|FA9_HUMAN Coagulation factor IX (Gene Name=F9)

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