Structure of PDB 6x5l Chain A

Receptor sequence
>6x5lA (length=233) Species: 9606 (Homo sapiens) [Search protein sequence]
VVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVEGVKITV
VAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVL
NSYVTPICIADKEYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLV
DRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLTG
IISWGEECAMKGKYGIYTKVSRYVNWIKEKTKL
3D structure
PDB6x5l Discovery of hydroxy pyrimidine Factor IXa inhibitors.
ChainA
Resolution2.246 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H56 D104 Q197 G198 D199 S200
Catalytic site (residue number reindexed from 1) H41 D88 Q181 G182 D183 S184
Enzyme Commision number 3.4.21.22: coagulation factor IXa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UQG A H56 K100 D194 S195 C196 Q197 S200 W220 G221 E223 C224 H41 K84 D178 S179 C180 Q181 S184 W204 G205 E207 C208 MOAD: ic50=44nM
BindingDB: IC50=44nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6x5l, PDBe:6x5l, PDBj:6x5l
PDBsum6x5l
PubMed32527459
UniProtP00740|FA9_HUMAN Coagulation factor IX (Gene Name=F9)

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