Structure of PDB 6x3c Chain A

Receptor sequence
>6x3cA (length=207) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
HGPDPENILPIKGNRNLQFIKPTITNENILVGEYSYYDSKRGESFEDQVL
YHYEVIGDKLIIGRFCSIGPGTTFIMNGANHRMDGSTYPFHLFRMGWEKY
MPSLKDLPLKGDIEIGNDVWIGRDVTIMPGVKIGDGAIIAAEAVVTKNVA
PYSIVGGNPLKFIRKRFSDGVIEEWLALQWWNLDMKIINENLPFIINGDI
EMLKRKR
3D structure
PDB6x3c Synthetic group A streptogramin antibiotics that overcome Vat resistance.
ChainA
Resolution3.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SXA A G75 W126 G128 R129 A146 A147 G69 W120 G122 R123 A140 A141
BS02 O7S A Y59 G84 N86 H87 H97 L98 M107 P108 L110 Y53 G78 N80 H81 H91 L92 M101 P102 L104
BS03 SXA A Y57 N86 H87 M134 Y51 N80 H81 M128
BS04 O7S A L23 Y42 L17 Y36
Gene Ontology
Molecular Function
GO:0016740 transferase activity
GO:0016746 acyltransferase activity
Biological Process
GO:0046677 response to antibiotic

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Molecular Function
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Biological Process
External links
PDB RCSB:6x3c, PDBe:6x3c, PDBj:6x3c
PDBsum6x3c
PubMed32968273
UniProtP26839|VATA_STAAU Virginiamycin A acetyltransferase (Gene Name=vat)

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