Structure of PDB 6x2f Chain A

Receptor sequence
>6x2fA (length=1144) Species: 562 (Escherichia coli) [Search protein sequence]
QYRYTLPVKAGEQRLLGELTGAACATLVAEIAERHAGPVVLIAPDMQNAL
RLHDEISQFTDQMVMNLADWETLPYDSFSPHQDIISSRLSTLYQLPTMQR
GVLIVPVNTLMQRVCPHSFLHGHALVMKKGQRLSRDALRTQLDSAGYRHV
DQVMEHGEYATRGALLDLFPMGSELPYRLDFFDDEIDSLRVFDVDSQRTL
EEVEAINLLPAHEFPTDKAAIELFRSQWRDTFEVKRDPEHIYQQVSKGTL
PAGIEYWQPLFFSEPLPPLFSYFPANTLLVNTGDLETSAERFQADTLARF
ENRGVDPMRPLLPPQSLWLRVDELFSELKNWPRVQLKTEHLPTKAANANL
GFQKLPDLAVQAQQKAPLDALRKFLETFDGPVVFSVESEGRREALGELLA
RIKIAPQRIMRLDEASDRGRYLMIGAAEHGFVDTVRNLALICESDLLGER
VARRRQDSRRTINPDTLIRNLAELHIGQPVVHLEHGVGRYAGMTTLEAGG
ITGEYLMLTYANDAKLYVPVSSLHLISRYAGGAEENAPLHKLGGDAWSRA
RQKAAEKVRDVAAELLDIYAQRAAKEGFAFKHDREQYQLFCDSFPFETTP
DQAQAINAVLSDMCQPLAMDRLVCGDVGFGKTEVAMRAAFLAVDNHKQVA
VLVPTTLLAQQHYDNFRDRFANWPVRIEMISRFRSAKEQTQILAEVAEGK
IDILIGTHKLLQSDVKFKDLGLLIVDEEHRFGVRHKERIKAMRANVDILT
LTATPIPRTLNMAMSGMRDLSIIATPPARRLAVKTFVREYDSMVVREAIL
REILRGGQVYYLYNDVENIQKAAERLAELVPEARIAIGHGQMRERELERV
MNDFHHQRFNVLVCTTIIETGIDIPTANTIIIERADHFGLAQLHQLRGRV
GRSHHQAYAWLLTPHPKAMTTDAQKRLEAIASLEDLGAGFALATHDLEIR
GAGELLGEEQSGSMETIGFSLYMELLENAVDALKAGREPSLEDLTSQQTE
VELRMPSLLPDDFIPDVNTRLSFYKRIASAKTENELEEIKVELIDRFGLL
PDPARTLLDIARLRQQAQKLGIRKLEGNEKGGVIEFAEKNHVNPAWLIGL
LQKQPQHYRLDGPTRLKFIQDLSERKTRIEWVRQFMRELEENAI
3D structure
PDB6x2f Structural basis for transcription complex disruption by the Mfd translocase.
ChainA
Resolution4.0 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A R201 R552 Q555 R685 H711 K712 G843 Q844 T869 R198 R549 Q552 R682 H708 K709 G840 Q841 T866
BS02 dna A R733 H890 Q895 R929 R953 E961 R730 H887 Q892 R926 R950 E958
BS03 ADP A F597 F599 E600 Q605 G631 G633 K634 T635 P780 F594 F596 E597 Q602 G628 G630 K631 T632 P777
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015616 DNA translocase activity
GO:0016787 hydrolase activity
GO:0043175 RNA polymerase core enzyme binding
Biological Process
GO:0000716 transcription-coupled nucleotide-excision repair, DNA damage recognition
GO:0006281 DNA repair
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006294 nucleotide-excision repair, preincision complex assembly
GO:0006355 regulation of DNA-templated transcription
GO:0006974 DNA damage response
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:1990391 DNA repair complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6x2f, PDBe:6x2f, PDBj:6x2f
PDBsum6x2f
PubMed33480355
UniProtP30958|MFD_ECOLI Transcription-repair-coupling factor (Gene Name=mfd)

[Back to BioLiP]