Structure of PDB 6wzb Chain A

Receptor sequence
>6wzbA (length=411) Species: 70601 (Pyrococcus horikoshii OT3) [Search protein sequence]
KYIEYPVLQKILIGLILGAIVGLILGHYGYADAVKTYVKPFGDLFVRLLK
MLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMAR
LFNPGAGIHLAVGGQQFQPKQAPPLVKILLDIVPTNPFGALANGQVLPTI
FFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYA
PIGVFALIAYCMAEQGVKVVGELAKVTAAVYVGLTLQILLVYFVLLKIYG
IDPISFIKKAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPL
GATINMDGTALYQGVSTFFIANALGSHLTVGQQLTIVLTAVLASIGTAGV
PGAGAIMLAMVLESVGLPLTDPNVAAAYAMILCIDAILDMGRTMVNVTGD
LTGTAIVAKTE
3D structure
PDB6wzb Glutamate transporters have a chloride channel with two hydrophobic gates.
ChainA
Resolution3.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ASP A S277 S278 T314 T352 G354 V355 A358 G359 D394 R397 T398 N401 S272 S273 T309 T347 G349 V350 A353 G354 D389 R392 T393 N396
BS02 NA A T308 M311 S349 I350 G351 T352 T303 M306 S344 I345 G346 T347
BS03 NA A S278 G306 A307 N310 N401 V402 D405 S273 G301 A302 N305 N396 V397 D400
Gene Ontology
Molecular Function
GO:0005283 amino acid:sodium symporter activity
GO:0015108 chloride transmembrane transporter activity
GO:0015183 L-aspartate transmembrane transporter activity
GO:0015293 symporter activity
GO:0015501 glutamate:sodium symporter activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006865 amino acid transport
GO:0035725 sodium ion transmembrane transport
GO:0046942 carboxylic acid transport
GO:0070207 protein homotrimerization
GO:0070778 L-aspartate transmembrane transport
GO:0140009 L-aspartate import across plasma membrane
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:6wzb, PDBe:6wzb, PDBj:6wzb
PDBsum6wzb
PubMed33597752
UniProtO59010|GLT_PYRHO Glutamate transporter homolog (Gene Name=PH1295)

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