Structure of PDB 6wyj Chain A

Receptor sequence
>6wyjA (length=397) Species: 70601 (Pyrococcus horikoshii OT3) [Search protein sequence]
KYIEYPVLQKILIGLILGAIVGLILGHYGYADAVKTYVKPFGDLFVRLLK
MLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGIIMAR
LFNPGAGIHPLVKILLDIVPTNPFGALANGQVCPTIFFAIILGIAITYLM
NSENEKVRKSAETLLDAINGLAEAMYKIVNGVMQYAPIGVFALIAYVMAE
QGVKVVGELAKVTAAVYVGLTLQILLVYFVLLKIYGIDPISFIKKAKDAM
LTAFVTRSSSGTLPVTMRVAKEMGISEGIYSFTLPLGATINMDGTALYQG
VSTFFIANALGSHLTVGQQLTIVLTAVLASICTAGVPGAGAIMLAMVLES
VGLPLTDPNVAAAYAMILGIDAILDMGRTMVNVTGDLTGTAIVAKTE
3D structure
PDB6wyj Glutamate transporters have a chloride channel with two hydrophobic gates.
ChainA
Resolution3.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ASP A S277 S278 G354 V355 D394 R397 T398 S258 S259 G335 V336 D375 R378 T379
Gene Ontology
Molecular Function
GO:0005283 amino acid:sodium symporter activity
GO:0015108 chloride transmembrane transporter activity
GO:0015183 L-aspartate transmembrane transporter activity
GO:0015293 symporter activity
GO:0015501 glutamate:sodium symporter activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006865 amino acid transport
GO:0035725 sodium ion transmembrane transport
GO:0046942 carboxylic acid transport
GO:0070207 protein homotrimerization
GO:0070778 L-aspartate transmembrane transport
GO:0140009 L-aspartate import across plasma membrane
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:6wyj, PDBe:6wyj, PDBj:6wyj
PDBsum6wyj
PubMed33597752
UniProtO59010|GLT_PYRHO Glutamate transporter homolog (Gene Name=PH1295)

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