Structure of PDB 6wxv Chain A

Receptor sequence

>6wxvA (length=1091) Species: 10090 (Mus musculus)

QNSISWEVQRFDGWYNNLMEHRWGSKGSRLQRLVPASYADGVYQPLKEPY
LPNPRHLSNRVMRGSAGQPSLRNRTVLGVFFGYHVLSDLVSVETPGCPAE
FLNIYIPHGDPVFDPDKRGNVVLPFQRSRWDRNTGQSPSNPRDQSNQVTG
WLDGSAIYGSSHSWSDTLRSFSGGQLASGPDPAFPSDSQSSLLMWMAPDP
STGQGGPRGVYAFGAQRGNREPFLQALGLLWFRYHNLCARKLAQEHPHWG
DEELFQHARKRVIATYQNIAMYEWLPSFLKQTPPEYPGYRPFLDPSISPE
FVVASEQFLSTMVPSGVYMRNASCHFQGSGALRVCNSYWSREHPKLQRAE
DVDALLLGMASQIAEREDHVVVEDMQDFWPGPLKFSRTDYLASCLQRGRD
LGLPSYTKAREALGLSPISHWQDINPALSRSNGTVLEATAALYNQDLSRL
ELLPGGLLESHGDPGPLFSTIVLDQFVRLRDGDRYWFENTRNGLFSKEEI
AEIRNTSLRDILVAVTNVDPSALQPNVFFWLAGDPCPQPSQLSAKGLPAC
APLFIRDYFEGSGFGFGLTIGTLCCFPLVSLLSAWIVARLRKRNHQTVQQ
FKRFIENYRRHIGCVAVFYTITGALFLERAYYYAFAAHHSGITDTTRVGI
ILSRGTAASISFMFSYILLTMCRNLITFLRETFLNRYIPFDAAVDFHRLI
ASTAIILTVLHSAGHVVNVYLFSISPLSVLSCLFPGLFHDDGSEFPQKYY
WWFFQTVPGLTGVLLLLALAIMYVFASHHFRRRSFRGFWLTHHLYIFLYI
LLIIHGSFALIQMPRFHIFFLVPAIIYVGDKLVSLSRKKVEISVVKAELL
PSGVTHLRFQRPQGFEYKSGQWVRIACLALGTTEYHPFTLTSAPHEDTLS
LHIRAAGPWTTRLREIYSPPRYPKLYLDGPFGEGHQEWHKFEVSVLVGGG
IGVTPFASILKDLVFKSSVSCCKKIYFIWVTRTQRQFEWLADIIREVEEN
DRQDLVSVHIYITQLAEKFDLRVLNRSLFTGLRSITHFGRPPFEPFFNSL
QEVHPQKIGVFSCGPPGMTKNVEKACQLINRQDFSHHYENF

3D structure

• PDB: 6wxv Structures of mouse DUOX1-DUOXA1 provide mechanistic insights into enzyme activation and regulation.
• Chain: A
• Resolution: 3.3 Å

Enzymatic activity

• Enzyme Commision number: 1.6.3.1: NAD(P)H oxidase (H2O2-forming).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	A	D1128 H1319 P1320 F1321 T1322 H1335 R1337 A1339 G1340 W1342	D695 H886 P887 F888 T889 H902 R904 A906 G907 W909
BS02	HEB	A	M1104 R1106 H1130 A1134 M1205 F1221 H1225	M671 R673 H697 A701 M772 F788 H792
BS03	HEB	A	R1087 I1093 T1141 H1144 H1148 P1191 G1195 L1199 H1238 G1239	R654 I660 T708 H711 H715 P758 G762 L766 H805 G806
BS04	NDP	A	G1391 T1423 R1424 T1455 R1495 P1522 G1524 M1525	G952 T981 R982 T1013 R1040 P1065 G1067 M1068
BS05	CA	A	D109 T170 W172 S176	D88 T149 W151 S155

Gene Ontology

Molecular Function

• GO:0004601 peroxidase activity
• GO:0005509 calcium ion binding
• GO:0016491 oxidoreductase activity
• GO:0020037 heme binding

Biological Process

• GO:0006979 response to oxidative stress

External links

• PDB: RCSB:6wxv, PDBe:6wxv, PDBj:6wxv
• PDBsum: 6wxv
• PubMed: 32929281
• UniProt: A2AQ92