Structure of PDB 6wxu Chain A

Receptor sequence
>6wxuA (length=834) Species: 10090 (Mus musculus) [Search protein sequence]
NSISWEVQRFDGWYNNLMEHRWGSKGSRLQRLVPASYADGVYQPLKEPYL
PNPRHLSNRVMRGSAGQPSLRNRTVLGVFFGYHVLSDLVSVETPGCPAEF
LNIYIPHGDPVFDPDKRGNVVLPFQRSRWDRNTGQSPSNPRDQSNQVTGW
LDGSAIYGSSHSWSDTLRSFSGGQLASGPDPAFPSDSQSSLLMWMAPDPS
TGQGGPRGVYAFGAQRGNREPFLQALGLLWFRYHNLCARKLAQEHPHWGD
EELFQHARKRVIATYQNIAMYEWLPSFLKQTPPEYPGYRPFLDPSISPEF
VVASEQFLSTMVPSGVYMRNASCHFQGISGALRVCNSYWSREHPKLQRAE
DVDALLLGMASQIAEREDHVVVEDMQDFWPGPLKFSRTDYLASCLQRGRD
LGLPSYTKAREALGLSPISHWQDINPALSRSNGTVLEATAALYNQDLSRL
ELLPGGLLESHGDPGPLFSTIVLDQFVRLRDGDRYWFENTRNGLFSKEEI
AEIRNTSLRDILVAVTNVDPSALQPNVFFWLAGDPCPQPSQLSAKGLPAC
APLFIRDYFEGSGFGFGLTIGTLCCFPLVSLLSAWIVARLRKRTVQQFKR
FIENYRRHIGCVAVFYTITGALFLERAYYYAFAAHHSGITDTTRVGIILS
RGTAASISFMFSYILLTMCRNLITFLRETFLNRYIPFDAAVDFHRLIAST
AIILTVLHSAGHVVNVYLFSISPLSVLSCLFPGLFHDDGSEFPQKYYWWF
FQTVPGLTGVLLLLALAIMYVFASHHFRRRSFRGFWLTHHLYIFLYILLI
IHGSFALIQMPRFHIFFLVPAIIYVGDKLVSLSR
3D structure
PDB6wxu Structures of mouse DUOX1-DUOXA1 provide mechanistic insights into enzyme activation and regulation.
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.6.3.1: NAD(P)H oxidase (H2O2-forming).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MAN A D61 Q157 D39 Q135
BS02 MAN A A1069 H1071 H1072 A633 H635 H636
BS03 HEC A M1104 R1106 H1130 A1134 M1205 Y1206 A1209 F1221 H1225 Y1228 M668 R670 H694 A698 M769 Y770 A773 F785 H789 Y792
BS04 HEC A H1144 H1148 P1191 G1195 H1238 L1243 F1249 H708 H712 P755 G759 H802 L807 F813
Gene Ontology
Molecular Function
GO:0004601 peroxidase activity
GO:0005509 calcium ion binding
GO:0016491 oxidoreductase activity
GO:0020037 heme binding
Biological Process
GO:0006979 response to oxidative stress

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Molecular Function
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Biological Process
External links
PDB RCSB:6wxu, PDBe:6wxu, PDBj:6wxu
PDBsum6wxu
PubMed32929281
UniProtA2AQ92

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