Structure of PDB 6ww8 Chain A

Receptor sequence
>6ww8A (length=131) Species: 9606 (Homo sapiens) [Search protein sequence]
TNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKL
NLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKP
GDDIVLMAEALEKLFLQKINELPTEETEIMI
3D structure
PDB6ww8 A triple action CDK4/6-PI3K-BET inhibitor with augmented cancer cell cytotoxicity.
ChainA
Resolution2.302 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YR0 A W81 P82 V87 L92 N140 W39 P40 V45 L50 N98
External links
PDB RCSB:6ww8, PDBe:6ww8, PDBj:6ww8
PDBsum6ww8
PubMed32793389
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

[Back to BioLiP]