Structure of PDB 6wv6 Chain A

Receptor sequence
>6wv6A (length=381) Species: 6100,9606 [Search protein sequence]
SKGEELFTGVVPILVELDGDVNGHKFSVRGEGEGDATNGKLTLKFICTTG
KLPVPWPTLVTTLVQCFSRYPDHMKRHDFFKSAMPEGYVQERTISFKDDG
TYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNSTWGSPGWVR
LALCLTGLVLSLYALHVKAARARDRDYRALCDVGTAISCSRVFSSRWGRG
FGLVEHVLGQDSILNQSNSIFGCIFYTLQLLLGCLRTRWASVLMLLSSLV
SLAGSVYLAWILFFVLYDFCIVCITTYAINVSLMWLSFRKVQENSHNVYI
TADKQKNGIKANFKIRHNVEDGSVQLADHYQQNTPIGDGPVLLPDNHYLS
TQSVLSKDPNEKRDHMVLLEFVTAAGITHHH
3D structure
PDB6wv6 Structural basis of antagonizing the vitamin K catalytic cycle for anticoagulation.
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.17.4.4: vitamin-K-epoxide reductase (warfarin-sensitive).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UAS A A168 V196 F197 N222 S223 L262 C277 Y281 A164 V192 F193 N218 S219 L258 C273 Y277
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016728 oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor
GO:0047057 vitamin-K-epoxide reductase (warfarin-sensitive) activity
GO:0047058 vitamin-K-epoxide reductase (warfarin-insensitive) activity
GO:0048038 quinone binding
Biological Process
GO:0006091 generation of precursor metabolites and energy
GO:0006805 xenobiotic metabolic process
GO:0007596 blood coagulation
GO:0008218 bioluminescence
GO:0014070 response to organic cyclic compound
GO:0017187 peptidyl-glutamic acid carboxylation
GO:0030193 regulation of blood coagulation
GO:0042373 vitamin K metabolic process
GO:0050820 positive regulation of coagulation
GO:0060348 bone development
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6wv6, PDBe:6wv6, PDBj:6wv6
PDBsum6wv6
PubMed33154105
UniProtP42212|GFP_AEQVI Green fluorescent protein (Gene Name=GFP);
Q9BQB6

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