Structure of PDB 6wto Chain A

Receptor sequence
>6wtoA (length=279) Species: 9606 (Homo sapiens) [Search protein sequence]
QFEERHLKFLQQLGKGNFGSVEMCRYDPLTGEVVAVKKLQHSTEEHLRDF
EREIEILKSLQHDNIVKYKGVCYLKLIMEYLPYGSLRDYLQKHKERIDHI
KLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVL
PQDKEYYKVKSPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSK
SPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTEC
WNNNVNQRPSFRDLALRVDQIRDNMAGGS
3D structure
PDB6wto Degradation of Janus kinases in CRLF2-rearranged acute lymphoblastic leukemia.
ChainA
Resolution1.74 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D976 R980 N981 D994
Catalytic site (residue number reindexed from 1) D125 R129 N130 D143
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3JW A L855 G856 V863 A880 M929 L932 R980 L983 G993 D994 L13 G14 V21 A35 M78 L81 R129 L132 G142 D143 BindingDB: IC50=5.7nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6wto, PDBe:6wto, PDBj:6wto
PDBsum6wto
PubMed34110416
UniProtO60674|JAK2_HUMAN Tyrosine-protein kinase JAK2 (Gene Name=JAK2)

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