Structure of PDB 6wr4 Chain A

Receptor sequence
>6wr4A (length=470) Species: 9606 (Homo sapiens) [Search protein sequence]
PWHHIENLDLFFSRVYNLHQKNGFTCMLIGEIFELMQFLFVVAFTTFLVS
CVDYDILFANKVTLPDAFLPAQVCSARIQENGSLITILVIAGVFWIHRLI
KFIYNICCYWEIHSFYLHALRIPMSALPYCTWQEVQARIVQTQKEHQIRE
LTELDIYHRILRFQNYMVALVNKSLLPLRFRLPGLGEAVFFTRGLKYNFE
LILFWGPGSLFLNEWSLKAEYKRGGQRLELAQRLSNRILWIGIANFLLCP
LILIWQILYAFFSYAEVLKREPGALGARCWSLYGRCYLRHFNELEHELQS
RLNRGYKPASKYMNCFLSPLLTLLAKNGAFFAGSILAVLIALTIYDEDVL
AVEHVLTTVTLLGVTVTVCRSFIPDQHMVFCPEQLLRVILAHIHYMPDHW
QGNAHRSQTRDEFAQLFQYKAVFILEELLSPIVTPLILIFCLRPRALEII
DFFRNFTVEVVGVGDTCSFA
3D structure
PDB6wr4 Structure of Human ATG9A, the Only Transmembrane Protein of the Core Autophagy Machinery.
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LMN A A139 R245 Y249 L253 N297 W307 Y311 A91 R193 Y197 L201 N245 W255 Y259
BS02 LMN A F142 Y249 W257 E266 L300 F94 Y197 W205 E214 L248
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0017128 phospholipid scramblase activity
Biological Process
GO:0000045 autophagosome assembly
GO:0000422 autophagy of mitochondrion
GO:0006869 lipid transport
GO:0006914 autophagy
GO:0017121 plasma membrane phospholipid scrambling
GO:0034497 protein localization to phagophore assembly site
GO:0034727 piecemeal microautophagy of the nucleus
GO:0060349 bone morphogenesis
GO:0061709 reticulophagy
GO:0097300 programmed necrotic cell death
Cellular Component
GO:0000139 Golgi membrane
GO:0000407 phagophore assembly site
GO:0000421 autophagosome membrane
GO:0005739 mitochondrion
GO:0005768 endosome
GO:0005770 late endosome
GO:0005776 autophagosome
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0016020 membrane
GO:0031902 late endosome membrane
GO:0031966 mitochondrial membrane
GO:0034045 phagophore assembly site membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0055037 recycling endosome
GO:0055038 recycling endosome membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6wr4, PDBe:6wr4, PDBj:6wr4
PDBsum6wr4
PubMed32610138
UniProtQ7Z3C6|ATG9A_HUMAN Autophagy-related protein 9A (Gene Name=ATG9A)

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