Structure of PDB 6wok Chain A

Receptor sequence
>6wokA (length=225) Species: 9606 (Homo sapiens) [Search protein sequence]
LALSLTADQMVSALLDAEPPILYSEYDSMMGLLTNLADRELVHMINWAKR
VPGFVDLTSHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRN
QGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTSLE
EKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNK
GMEHLYSMKCKNVVPSYDLLLEMLD
3D structure
PDB6wok Discovery of GNE-149 as a Full Antagonist and Efficient Degrader of Estrogen Receptor alpha for ER+ Breast Cancer.
ChainA
Resolution2.309 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 U6D A M343 L346 T347 L349 A350 D351 L391 R394 F404 M421 I424 G521 L525 V533 P535 M30 L33 T34 L36 A37 D38 L78 R81 F91 M108 I111 G201 L205 V213 P215 MOAD: ic50=1.6nM
BindingDB: IC50=0.079433nM
BS02 G9J A L346 T347 A350 M388 F404 M421 I424 G521 L33 T34 A37 M75 F91 M108 I111 G201
External links
PDB RCSB:6wok, PDBe:6wok, PDBj:6wok
PDBsum6wok
PubMed32551022
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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