Structure of PDB 6wod Chain A

Receptor sequence
>6wodA (length=134) Species: 9606 (Homo sapiens) [Search protein sequence]
TRTYDGDGYKKRAACLCFRSESEEEVLLVSSSRHPDRWIVPGGGMEPEEE
PSVAAVREVCEEAGVKGTLGRLVGIFENQERKHRTYVYVLIVTEVLEDWE
DSVNIGRKREWFKIEDAIKVLQYHKPVQASYFET
3D structure
PDB6wod New structural insights reveal an expanded reaction cycle for inositol pyrophosphate hydrolysis by human DIPP1.
ChainA
Resolution1.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.10: endopolyphosphatase.
3.6.1.52: diphosphoinositol-polyphosphate diphosphatase.
3.6.1.59: 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase.
3.6.1.61: diadenosine hexaphosphate hydrolase (ATP-forming).
3.6.1.62: 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A G50 E70 G42 E62
BS02 IHP A R10 K18 R20 S39 S40 R41 I47 G51 R89 R115 K133 R2 K10 R12 S31 S32 R33 I39 G43 R81 R107 K125
Gene Ontology
Molecular Function
GO:0016462 pyrophosphatase activity
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:6wod, PDBe:6wod, PDBj:6wod
PDBsum6wod
PubMed33475202
UniProtO95989|NUDT3_HUMAN Diphosphoinositol polyphosphate phosphohydrolase 1 (Gene Name=NUDT3)

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