Structure of PDB 6wmi Chain A

Receptor sequence

>6wmiA (length=146) Species: 9606 (Homo sapiens) [Search protein sequence]

KKLKCTVEGCDRTFVWPAHFKYHLKTHRNDRSFICPAEGCGKSFYVLQRL
KVHMRTHNGEKPFMCHESGCGKQFTTAGNLKNHRRIHTGEKPFLCEAQGC
GRSFAEYSSLRKHLVVHSGEKPHQCQVCGKTFSQSGSRNVHMRKHH

3D structure

PDB

6wmi ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression.

Chain

Resolution

2.75 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	H282 R300	H66 R84
BS02	dna	A	R228 W232 H235 Y238 R247 R265 H269 T272 N295 H299 R318 E322 S325 H329 Q350	R12 W16 H19 Y22 R31 R49 H53 T56 N79 H83 R102 E106 S109 H113 Q134
BS03	dna	A	L263 Q264 Y323 S324 R327	L47 Q48 Y107 S108 R111
BS04	ZN	A	C281 C286 H299 H303	C65 C70 H83 H87
BS05	ZN	A	C221 C226 H239 H243	C5 C10 H23 H27
BS06	ZN	A	C311 C316 H329 H333	C95 C100 H113 H117
BS07	ZN	A	C251 C256 H269 H273	C35 C40 H53 H57
BS08	ZN	A	C344 H357 H361	C128 H141 H145

External links

PDB	RCSB:6wmi, PDBe:6wmi, PDBj:6wmi
PDBsum	6wmi
PubMed	33301730
UniProt	Q86VK4\|ZN410_HUMAN Zinc finger protein 410 (Gene Name=ZNF410)