Structure of PDB 6wkj Chain A

Receptor sequence
>6wkjA (length=251) Species: 1931 (Streptomyces sp.) [Search protein sequence]
IPLPGRQSPDHARAEAEQLAWPRSLGLIRSDAAAERHLRGGYADLASRFY
PHATGADLDLGVDLMSWHFLFDDLFDPRGEPEDTKQLTDQVAAALDGPLP
DTAPPIAHGFADIWRRTCEGMTPAWCARSARHWRNYFDGYVDEAERRHTI
GVQPTVDLAERAGRFEVPHRVFDSAVMSAMLQIAVDVNLLLNDIAHMQNE
VRARLEQYLLLESCLPKVGEIYQLDTAEREALERYRTDAVRTVIRGSYDW
H
3D structure
PDB6wkj Mechanism Underlying Anti-Markovnikov Addition in the Reaction of Pentalenene Synthase.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H76 F77 D80 D84 R173 I177 N219 W308 H309
Catalytic site (residue number reindexed from 1) H68 F69 D72 D76 R146 I150 N192 W250 H251
Enzyme Commision number 4.2.3.7: pentalenene synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FDF A L72 M73 H76 F77 D80 Y146 G178 V179 T182 N219 L64 M65 H68 F69 D72 Y136 G151 V152 T155 N192
Gene Ontology
Molecular Function
GO:0016829 lyase activity
GO:0046872 metal ion binding
GO:0050467 pentalenene synthase activity
Biological Process
GO:0017000 antibiotic biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6wkj, PDBe:6wkj, PDBj:6wkj
PDBsum6wkj
PubMed32786410
UniProtQ55012|PENA_STREX Pentalenene synthase (Gene Name=penA)

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