Structure of PDB 6wkh Chain A

Receptor sequence
>6wkhA (length=267) Species: 1931 (Streptomyces sp.) [Search protein sequence]
HIPLPGRQSPDHARAEAEQLAWPRSLGLIRSDAAAERHLRGGYADLASRF
YPHATGADLDLGVDLMSWWFLFDDLFDGPRGENPEDTKQLTDQVAAALDG
PLPDTAPPIAHGFADIWRRTCEGMTPAWCARSARHWRNYFDGYVDEAESR
AAQYLAMRRHTIGVQPTVDLAERAGRFEVPHRVFDSAVMSAMLQIAVDVN
LLLNDIASVSHMQNEVRARLEQYLLLESCLPKVGEIYQLDTAEREALERY
RTDAVRTVIRGSYDWHR
3D structure
PDB6wkh Mechanism Underlying Anti-Markovnikov Addition in the Reaction of Pentalenene Synthase.
ChainA
Resolution2.55 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) W76 F77 D80 D84 R157 R173 I177 N219 W308 H309
Catalytic site (residue number reindexed from 1) W69 F70 D73 D77 R150 R158 I162 N204 W265 H266
Enzyme Commision number 4.2.3.7: pentalenene synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FDF A W76 F77 D80 R173 N219 W69 F70 D73 R158 N204
Gene Ontology
Molecular Function
GO:0016829 lyase activity
GO:0046872 metal ion binding
GO:0050467 pentalenene synthase activity
Biological Process
GO:0017000 antibiotic biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6wkh, PDBe:6wkh, PDBj:6wkh
PDBsum6wkh
PubMed32786410
UniProtQ55012|PENA_STREX Pentalenene synthase (Gene Name=penA)

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