Structure of PDB 6wkf Chain A

Receptor sequence
>6wkfA (length=269) Species: 1931 (Streptomyces sp.) [Search protein sequence]
PLPGRQSPDHARAEAEQLAWPRSLGLIRSDAAAERHLRGGYADLASRFYP
HATGADLDLGVDLMSWYFLFDDLFDPRGENPEDTKQLTDQVAAALDGPLP
DTAPPIAHGFADIWRRTCEGMTPAWCARSARHWRNYFDGYVDEAESRFAQ
YLAMRRHTIGVQPTVDLAERAGRFEVPHRVFDSAVMSAMLQIAVDVNLLL
NDIASLEKNMVMSHMQNEVRARLEQYLLLESCLPKVGEIYQLDTAEREAL
ERYRTDAVRTVIRGSYDWH
3D structure
PDB6wkf Mechanism Underlying Anti-Markovnikov Addition in the Reaction of Pentalenene Synthase.
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y76 F77 D80 D84 R157 R173 I177 N219 S223 K226 W308 H309
Catalytic site (residue number reindexed from 1) Y67 F68 D71 D75 R147 R155 I159 N201 S205 K208 W268 H269
Enzyme Commision number 4.2.3.7: pentalenene synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FDF A Y76 F77 D80 R173 I177 N219 Y67 F68 D71 R155 I159 N201
Gene Ontology
Molecular Function
GO:0016829 lyase activity
GO:0046872 metal ion binding
GO:0050467 pentalenene synthase activity
Biological Process
GO:0017000 antibiotic biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6wkf, PDBe:6wkf, PDBj:6wkf
PDBsum6wkf
PubMed32786410
UniProtQ55012|PENA_STREX Pentalenene synthase (Gene Name=penA)

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