Structure of PDB 6wkd Chain A

Receptor sequence
>6wkdA (length=280) Species: 1931 (Streptomyces sp.) [Search protein sequence]
IPLPGRQSPDHARAEAEQLAWPRSLGLIRSDAAAERHLRGGYADLASRFY
PHATGADLDLGVDLMSWFFLFDDLFDGPRGENPEDTKQLTDQVAAALDGP
LPDTAPPIAHGFADIWRRTCEGMTPAWCARSARHWRNYFDGYVDEAESRF
AAQYLAMRRHTIGVQPTVDLAERAGRFEVPHRVFDSAVMSAMLQIAVDVN
LLLNDIASLNMVMIRSVSHMQNEVRARLEQYLLLESCLPKVGEIYQLDTA
EREALERYRTDAVRTVIRGSYDWHRSSGRY
3D structure
PDB6wkd Mechanism Underlying Anti-Markovnikov Addition in the Reaction of Pentalenene Synthase.
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) F76 F77 I177 R314
Catalytic site (residue number reindexed from 1) F68 F69 I162 R279
Enzyme Commision number 4.2.3.7: pentalenene synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FDF A F76 F77 Y146 R173 I177 N219 W308 R314 Y315 F68 F69 Y138 R158 I162 N204 W273 R279 Y280
BS02 MG A D80 D84 D72 D76
BS03 MG A N219 S223 N204 S208
Gene Ontology
Molecular Function
GO:0016829 lyase activity
GO:0046872 metal ion binding
GO:0050467 pentalenene synthase activity
Biological Process
GO:0017000 antibiotic biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6wkd, PDBe:6wkd, PDBj:6wkd
PDBsum6wkd
PubMed32786410
UniProtQ55012|PENA_STREX Pentalenene synthase (Gene Name=penA)

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