Structure of PDB 6wjc Chain A

Receptor sequence
>6wjcA (length=445) Species: 9606,10665 [Search protein sequence]
APGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLS
LACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASQARVMNL
LLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQY
LVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETE
NRNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKA
IGRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAAL
INMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRV
ITTFRTGTWDAYFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCK
DCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRW
3D structure
PDB6wjc Structure and selectivity engineering of the M1muscarinic receptor toxin complex.
ChainA
Resolution2.55 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.2.1.17: lysozyme.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Y01 A Q24 F27 T398 L402 W405 V409 Q8 F11 T406 L410 W413 V417
BS02 Y01 A Y62 C69 P139 W150 Y46 C53 P123 W134
BS03 Y01 A F50 K51 K57 F34 K35 K41
BS04 OIN A D105 Y106 S109 A193 W378 Y381 N382 Y404 D89 Y90 S93 A177 W386 Y389 N390 Y412
Gene Ontology
Molecular Function
GO:0003796 lysozyme activity
GO:0004930 G protein-coupled receptor activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0016907 G protein-coupled acetylcholine receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0009253 peptidoglycan catabolic process
GO:0016998 cell wall macromolecule catabolic process
GO:0031640 killing of cells of another organism
GO:0040012 regulation of locomotion
GO:0042742 defense response to bacterium
GO:0044659 viral release from host cell by cytolysis
GO:0046541 saliva secretion
GO:0050890 cognition
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030430 host cell cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6wjc, PDBe:6wjc, PDBj:6wjc
PDBsum6wjc
PubMed32646996
UniProtD9IEF7;
P11229|ACM1_HUMAN Muscarinic acetylcholine receptor M1 (Gene Name=CHRM1)

[Back to BioLiP]