Structure of PDB 6wj4 Chain A

Receptor sequence
>6wj4A (length=179) Species: 11320 (Influenza A virus) [Search protein sequence]
GSHMEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVCFM
YSDGGSKHRFEIIEGRDRIMAWTVVNSICNTTGVEKPKFLPDLYDYKENR
FIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEE
SRARIKTRLFTIRQEMASRSLWDSFRQSE
3D structure
PDB6wj4 Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential.
ChainA
Resolution2.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A H41 D108 E119 I120 H44 D92 E103 I104
BS02 MN A E80 D108 E64 D92
BS03 U3A A Y24 H41 D108 E119 Y27 H44 D92 E103
BS04 QQ4 A M12 F46 I78 M15 F49 I62
Gene Ontology
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:6wj4, PDBe:6wj4, PDBj:6wj4
PDBsum6wj4
PubMed36603507
UniProtC6H0Y9

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