Structure of PDB 6wi3 Chain A

Receptor sequence
>6wi3A (length=372) Species: 9606 (Homo sapiens) [Search protein sequence]
SQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKME
IYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPV
FDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCY
VNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYG
EYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMY
QPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGG
YTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTN
QNTPEYMEKIKQRLFENLRMLP
3D structure
PDB6wi3 Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites.
ChainA
Resolution2.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.-
3.5.1.98: histone deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A G32 H33 P34 H146 G154 F155 H183 F210 L276 Y308 G25 H26 P27 H139 G147 F148 H176 F203 L269 Y301
BS02 ZN A D181 H183 D269 D174 H176 D262
Gene Ontology
Molecular Function
GO:0004407 histone deacetylase activity

View graph for
Molecular Function
External links
PDB RCSB:6wi3, PDBe:6wi3, PDBj:6wi3
PDBsum6wi3
PubMed34099674
UniProtQ92769|HDAC2_HUMAN Histone deacetylase 2 (Gene Name=HDAC2)

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