Structure of PDB 6wi2 Chain A

Receptor sequence
>6wi2A (length=402) Species: 9606 (Homo sapiens) [Search protein sequence]
SSLRPLYMDVQATTPLDPRVLDAMLPYLINYYGNPHSRTHAYGWESEAAM
ERARQQVASLIGADPREIIFTSGATESNNIAIKGVARFYRSRKKHLITTQ
TEHKCVLDSCRSLEAEGFQVTYLPVQKSGIIDLKELEAAIQPDTSLVSVM
TVNNEIGVKQPIAEIGRICSSRKVYFHTDAAQAVGKIPLDVNDMKIDLMS
ISGHKIYGPKGVGAIYIRRRPRVRVEALQSGGGQERGMRSGTVPTPLVVG
LGAACEVAQQEMEYDHKRISKLSERLIQNIMKSLPDVVMNGDPKHHYPGC
INLSFAYVEGESLLMALKDVALSSGSACTSASLEPSYVLRAIGTDEDLAH
SSIRFGIGRFTTEEEVDYTVEKCIQHVKRLREMSPLWEMVQDGIDLKSIK
WT
3D structure
PDB6wi2 The essential function of ISCU2 and its conserved N-terminus in Fe/S cluster biogenesis
ChainA
Resolution1.95 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H156 D232 A234 Q235 K258 S376 C381
Catalytic site (residue number reindexed from 1) H103 D179 A181 Q182 K205 S323 C328
Enzyme Commision number 2.8.1.7: cysteine desulfurase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP A G126 A127 T128 H156 D232 A234 Q235 S255 H257 K258 G73 A74 T75 H103 D179 A181 Q182 S202 H204 K205
Gene Ontology
Molecular Function
GO:0030170 pyridoxal phosphate binding
GO:0031071 cysteine desulfurase activity
Biological Process
GO:0044571 [2Fe-2S] cluster assembly

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Molecular Function
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Biological Process
External links
PDB RCSB:6wi2, PDBe:6wi2, PDBj:6wi2
PDBsum6wi2
PubMed
UniProtQ9Y697|NFS1_HUMAN Cysteine desulfurase (Gene Name=NFS1)

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