Structure of PDB 6wi0 Chain A

Receptor sequence

>6wi0A (length=792) Species: 10116 (Rattus norvegicus)

KIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQLQATSVTHKPNAIQM
ALSVCEDLISSQVYAILVSHPPTHFTPTPVSYTAGFYRIPVLGLTTRMSI
YSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYNWNHIILLVSDDHEGRAAQ
KRLETLLEEGPKAEKVLQFDPGTKNVTALLMEARELEARVIILSASEDDA
ATVYRAAAMLDMTGSGYVWLVGEREISGNALRYAPDGIIGLQLINGKNES
AHISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLMSS
KYADGVTGRVEFNEDGDRKFAQYSIMNLQNRKLVQVGIYNGTHVIPNDRK
IIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTMSDGTCKEEFTVNG
DPVKKVICTGPNDTSRHTVPQCCYGFCIDLLIKLARTMQFTYEVHLVADG
KFGTQERVQNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKP
FKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDR
FSTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTA
NLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVEL
STMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTT
GELFFRSGFGIGMRKDSPWKQQVSLSILKSHENGFMEDLDKTWVRYQECD
SRSNAPATLTCENMAGVFMLVAGGIVAGIFLIFIEIAYKRHK

3D structure

• PDB: 6wi0 Structural Basis of Functional Transitions in Mammalian NMDA Receptors.
• Chain: A
• Resolution: 4.27 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	QGM	A	Q426 F505 P537 L538 T539 V705 K706 S708 W752	Q377 F452 P484 L485 T486 V635 K636 S638 W682	BindingDB: Ki=6.3nM

Gene Ontology

Molecular Function

• GO:0005216 monoatomic ion channel activity
• GO:0015276 ligand-gated monoatomic ion channel activity
• GO:0038023 signaling receptor activity

Biological Process

• GO:0006811 monoatomic ion transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:6wi0, PDBe:6wi0, PDBj:6wi0
• PDBsum: 6wi0
• PubMed: 32610085
• UniProt: P35439|NMDZ1_RAT Glutamate receptor ionotropic, NMDA 1 (Gene Name=Grin1)