Structure of PDB 6whz Chain A

Receptor sequence
>6whzA (length=372) Species: 9606 (Homo sapiens) [Search protein sequence]
YSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKM
EIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCP
VFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFC
YVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKY
GEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEM
YQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGG
GYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMT
NQNTPEYMEKIKQRLFENLRML
3D structure
PDB6whz Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites.
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.-
3.5.1.98: histone deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A E103 D104 H146 G154 F155 H183 F210 Y308 E97 D98 H140 G148 F149 H177 F204 Y302
BS02 ZN A D181 H183 D269 D175 H177 D263
Gene Ontology
Molecular Function
GO:0004407 histone deacetylase activity

View graph for
Molecular Function
External links
PDB RCSB:6whz, PDBe:6whz, PDBj:6whz
PDBsum6whz
PubMed34099674
UniProtQ92769|HDAC2_HUMAN Histone deacetylase 2 (Gene Name=HDAC2)

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