Structure of PDB 6whe Chain A

Receptor sequence
>6wheA (length=172) Species: 9606 (Homo sapiens) [Search protein sequence]
TYDYLFKLLLIGDSGVGKTCVLFRFSEDAFNSTFISTIGIDFKIRTIELD
GKRIKLQIWDTAGLERFREITTAYYRGAMGIMLVYDITNEKSFDNIRNWI
RNIEEHASADVEKMILGNKCDVNDKRQVSKERGEKLALDYGIKFMETSAK
ANINVENAFFTLARDIKAKMDK
3D structure
PDB6whe Dual arginine recognition of LRRK2 phosphorylated Rab GTPases.
ChainA
Resolution1.73 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP A S17 G18 V19 G20 K21 T22 C23 F33 S35 F37 T40 G66 N121 K122 D124 S151 A152 K153 S14 G15 V16 G17 K18 T19 C20 F30 S32 F34 T37 G63 N118 K119 D121 S148 A149 K150
BS02 MG A T22 T40 T19 T37
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:6whe, PDBe:6whe, PDBj:6whe
PDBsum6whe
PubMed33887226
UniProtP61006|RAB8A_HUMAN Ras-related protein Rab-8A (Gene Name=RAB8A)

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