Structure of PDB 6wh5 Chain A

Receptor sequence
>6wh5A (length=186) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
VHLTRIYTRTGDDGTTGLSDMSRVAKTDARLVAYADCDEANAAIGAALAL
GHPDTQITDVLRQIQNDLFDAGADLSTPIVENPKHPPLRIAQSYIDRLEG
WCDAYNAGLPALKSFVLPGGSPLSALLHVARTVVRRAERSAWAAVDAHPE
GVSVLPAKYLNRLSDLLFILSRVANPDGDVLWRPGG
3D structure
PDB6wh5 Mobile loop dynamics in adenosyltransferase control binding and reactivity of coenzyme B 12 .
ChainA
Resolution1.866 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.17: corrinoid adenosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3PO A T10 R11 G13 T18 K28 T8 R9 G11 T16 K26
BS02 B12 A V3 H4 L5 T6 I8 M23 Y36 F71 G74 A75 P88 P89 L90 V1 H2 L3 T4 I6 M21 Y34 F69 G72 A73 P86 P87 L88
BS03 3PO A R137 N163 R135 N161
BS04 B12 A F117 V118 R133 R137 S166 D167 F170 F115 V116 R131 R135 S164 D165 F168
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008817 corrinoid adenosyltransferase activity
GO:0016740 transferase activity
Biological Process
GO:0006779 porphyrin-containing compound biosynthetic process
GO:0009236 cobalamin biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6wh5, PDBe:6wh5, PDBj:6wh5
PDBsum6wh5
PubMed33199623
UniProtP9WP99|PDUO_MYCTU Corrinoid adenosyltransferase (Gene Name=Rv1314c)

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