Structure of PDB 6wh0 Chain A

Receptor sequence

>6wh0A (length=524) Species: 562,6087

MKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQ
VAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRY
NGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMF
NLQEPYFTWPLIAADGGYAFKYKYDIKDVGVDNAGAKAGLTFLVDLIKNK
HMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKG
QPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAV
ALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAAS
GRQTVDEALKDAQTNSSSPNAQEDNYKRIVKSYVGEKLRKKGLKIRGYEG
EELKPPVIEIAKTLQRVGDELESANTDFFKNMCDQLQITPSTAYPTFQSI
ADEIFVSGKNWGRVVAFLTFGGNFAVHCALRADMGEEYVDRVVNWISKYM
AVNLDYWINQQGGWDGFLIFFEKT

3D structure

• PDB: 6wh0 The structural basis of Bcl-2 mediated cell death regulation in hydra.
• Chain: A
• Resolution: 1.99 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	E56 L57 N61 F64 I86 E89 I90 N96 G98 R99 V101 F106 F156 F157	E420 L421 N425 F428 I450 E453 I454 N460 G462 R463 V465 F470 F520 F521
BS02	GLC	A	D-356 K-355 E-259 Y-215 W-140	D15 K16 E112 Y156 W228
BS03	GLC	A	D-305 E-217 P-216 Y-215 W-30	D66 E154 P155 Y156 W338
BS04	GLC	A	E-326 R-304 E-217 P-216 W-30 Y-29 R-26	E45 R67 E154 P155 W338 Y339 R342

Gene Ontology

Molecular Function

• GO:0015144 carbohydrate transmembrane transporter activity
• GO:1901982 maltose binding

Biological Process

• GO:0008643 carbohydrate transport
• GO:0015768 maltose transport
• GO:0034219 carbohydrate transmembrane transport
• GO:0042956 maltodextrin transmembrane transport
• GO:0042981 regulation of apoptotic process
• GO:0055085 transmembrane transport

Cellular Component

• GO:0030288 outer membrane-bounded periplasmic space
• GO:0042597 periplasmic space
• GO:0055052 ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing

External links

• PDB: RCSB:6wh0, PDBe:6wh0, PDBj:6wh0
• PDBsum: 6wh0
• PubMed: 32776134
• UniProt: A7LM80;
  C3SHQ8