Structure of PDB 6wek Chain A

Receptor sequence
>6wekA (length=512) Species: 6239 (Caenorhabditis elegans) [Search protein sequence]
VRIRKYLANYTQDPSTDNFYYWTCVVTVAYIYNLLFVIARQVFNDLIGPS
SQSLCRFYTTQVECTYNMLTNMKEMPTYSQYPDLGWSKYWHFRMLWVFFD
LLMDCVYLIDTFLNYRMGYMDQGLVVREAEKVTKAYWQSKQYRIDGISLI
PLDYILGWPIPYINWRGLPILRLNRLIRYKRVRNCLERTETRSSMPNAFR
VVVVVWYIVIIIHWNACLYFWISEWIGLGTDAWVYGHLNKQSLPDDITDT
LLRRYVYSFYWSTLILTTIGEVPSPVRNIEYAFVTLDLMCGVLIFATIVG
NVGSMISNMSAARTEFQNKMDGIKQYMELRKVSKQLEIRVIKWFDYLWTN
KQSLSDQQVLKVLPDKLQAEIAMQVHFETLRKVRIFQDCEAGLLAELVLK
LQLQVFSPGDFICKKGDIGREMYIVKRGRLQVVDDDGKKVFVTLQEGSVF
GELSILNIAGSKNGNRRTANVRSVGYTDLFVLSKTDLWNALREYPDARKL
LLAKGREILKKD
3D structure
PDB6wek Mechanism of ligand activation of a eukaryotic cyclic nucleotide-gated channel.
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PCG A C521 G559 S562 R575 T576 A577 C413 G451 S454 R467 T468 A469
BS02 CPL A D147 L148 C172 Y197 W204 F207 D45 L46 C64 Y89 W96 F99
BS03 CPL A W329 I330 W221 I222
BS04 CPL A W314 Y315 W206 Y207
BS05 CPL A H321 T358 Y363 H213 T250 Y255
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity
GO:0005222 intracellularly cAMP-activated cation channel activity
GO:0005223 intracellularly cGMP-activated cation channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0030553 cGMP binding
GO:0042802 identical protein binding
GO:0044877 protein-containing complex binding
Biological Process
GO:0003031 detection of carbon dioxide
GO:0006811 monoatomic ion transport
GO:0006813 potassium ion transport
GO:0006935 chemotaxis
GO:0007199 G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
GO:0007399 nervous system development
GO:0007602 phototransduction
GO:0007635 chemosensory behavior
GO:0009454 aerotaxis
GO:0010628 positive regulation of gene expression
GO:0010754 negative regulation of cGMP-mediated signaling
GO:0019722 calcium-mediated signaling
GO:0030516 regulation of axon extension
GO:0034220 monoatomic ion transmembrane transport
GO:0040010 positive regulation of growth rate
GO:0040040 thermosensory behavior
GO:0042048 olfactory behavior
GO:0043052 thermotaxis
GO:0045664 regulation of neuron differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048609 multicellular organismal reproductive process
GO:0048812 neuron projection morphogenesis
GO:0050907 detection of chemical stimulus involved in sensory perception
GO:0055085 transmembrane transport
GO:0055093 response to hyperoxia
GO:0070482 response to oxygen levels
GO:0071805 potassium ion transmembrane transport
GO:0098655 monoatomic cation transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005929 cilium
GO:0016020 membrane
GO:0017071 intracellular cyclic nucleotide activated cation channel complex
GO:0030425 dendrite
GO:0034703 cation channel complex
GO:0042995 cell projection
GO:0097543 ciliary inversin compartment
GO:0097730 non-motile cilium

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6wek, PDBe:6wek, PDBj:6wek
PDBsum6wek
PubMed32483338
UniProtQ03611|CNG_CAEEL Cyclic nucleotide-gated channel (Gene Name=tax-4)

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