Structure of PDB 6we3 Chain A

Receptor sequence
>6we3A (length=180) Species: 9606 (Homo sapiens) [Search protein sequence]
KQQNFCVVELLPSDPEYNTVASKFNQTCSHFRIEKIERIQNPDLWNSYQA
KKKTMDAKNGQTMNEKQLFHGTDAGSVPHVNRNGFNRSYAGKNAVAYGKG
TYFAVNANYSANDTYSRPDANGRKHVYYVRVLTGIYTHGNHSLIVPPLYD
TVTDNVHHPSLFVAFYDYQAYPEYLITFRK
3D structure
PDB6we3 A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explants.
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TZ7 A H1682 G1683 D1685 K1704 Y1714 Y1721 S1722 Y1727 H70 G71 D73 K92 Y102 Y109 S110 Y115 BindingDB: IC50=<1000nM
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:6we3, PDBe:6we3, PDBj:6we3
PDBsum6we3
PubMed33705687
UniProtQ460N5|PAR14_HUMAN Protein mono-ADP-ribosyltransferase PARP14 (Gene Name=PARP14)

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