Structure of PDB 6we2 Chain A

Receptor sequence
>6we2A (length=189) Species: 9606 (Homo sapiens) [Search protein sequence]
KQQNFCVVELLPSDPEYNTVASKFNQTCSHFRIEKIERIQNPDLWNSYQA
KKKTMDAKNGQTMNEKQLFHGTDAGSVPHVNRNGFNRSYAGKNAVAYGKG
TYFAVNANYSANDTYSRPDANGRKHVYYVRVLTGIYTHGNHSLIVPPSKN
PQNPTDLYDTVTDNVHHPSLFVAFYDYQAYPEYLITFRK
3D structure
PDB6we2 A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explants.
ChainA
Resolution2.66 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XBA A H1682 G1683 D1685 Y1701 K1704 N1705 A1706 Y1709 Y1714 S1722 Y1727 H70 G71 D73 Y89 K92 N93 A94 Y97 Y102 S110 Y115 BindingDB: IC50=<1000nM
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:6we2, PDBe:6we2, PDBj:6we2
PDBsum6we2
PubMed33705687
UniProtQ460N5|PAR14_HUMAN Protein mono-ADP-ribosyltransferase PARP14 (Gene Name=PARP14)

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