Structure of PDB 6wbs Chain A

Receptor sequence
>6wbsA (length=215) Species: 9606 (Homo sapiens) [Search protein sequence]
TTTEVVMENVTAFWEEGGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLM
VIMGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIGDSYDEYRYRSV
IKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYL
LDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILH
EGSSYFYGTFSELQN
3D structure
PDB6wbs Determining the Molecular Mechanism of Suppressor Mutation V510D and the Contribution of Helical Unraveling to the dF508-CFTR Defect
ChainA
Resolution1.857 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.1.6: channel-conductance-controlling ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A W433 V440 T460 G461 G463 K464 T465 S466 Q493 W14 V21 T41 G42 G44 K45 T46 S47 Q74
BS02 MG A T465 Q493 T46 Q74
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:6wbs, PDBe:6wbs, PDBj:6wbs
PDBsum6wbs
PubMed
UniProtP13569|CFTR_HUMAN Cystic fibrosis transmembrane conductance regulator (Gene Name=CFTR)

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