Structure of PDB 6w9l Chain A

Receptor sequence
>6w9lA (length=249) Species: 32630 (synthetic construct) [Search protein sequence]
FPTLISLLEVIEPEVLYSGYDSTLPDTSTRLMSTLNRLGGRQVVSAVKWA
KALPGFRNLHLDDQMTLLQYSWMSLMAFSLGWRSYKQSNGNMLCFAPDLV
INEERMQLPYMYDQCQQMLKISSEFVRLQVSYDEYLCMKVLLLLSTVPKD
GLKSQAVFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEM
VGGLLQFCFYTFVNKSLSVEFPEMLAEIISNQLPKFKAGSVKPLLFHQK
3D structure
PDB6w9l Disruption of a key ligand-H-bond network drives dissociative properties in vamorolone for Duchenne muscular dystrophy treatment.
ChainA
Resolution1.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V44 K48 L58 M62 E220 M221 E224 V47 K51 L61 M65 E223 M224 E227
BS02 TUS A M29 L32 N33 Q39 M70 M73 F92 M108 Q111 M115 F204 C205 T208 M32 L35 N36 Q42 M73 M76 F95 M111 Q114 M118 F207 C208 T211
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
GO:0034056 estrogen response element binding
Biological Process
GO:0006357 regulation of transcription by RNA polymerase II
GO:0030518 nuclear receptor-mediated steroid hormone signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:6w9l, PDBe:6w9l, PDBj:6w9l
PDBsum6w9l
PubMed32917814
UniProtA0A1X8XLE9

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