Structure of PDB 6w8w Chain A

Receptor sequence

>6w8wA (length=828) Species: 10090 (Mus musculus) [Search protein sequence]

DRISWLGQPMKIEENRTYYQKVSIDEEMLEVGDCVSVIPDDSSKPLYLAR
VTALWEDKNGQMMFHAHWFCAGTDTVLGATSDPLELFLVGECENMQLSYI
HSKVKVIYKAPSENWAMEGGGKTYFFQLWYNQEYARFESPPKTQPTEDNK
HKFCLSCIRLAELRQKEMPKVLEQIEEVDGRVYCSSITKNGVVYRLGDSV
YLPPEAFTFNIKVASPVKRPKKDPVNETLYPEHYRKYSDYIKGSNLDAPE
PYRIGRIKEIHCGKKKGKVNEADIKLRLYKFYRPENTHRSYNGSYHTDIN
MLYWSDEEAVVNFSDVQGRCTVEYGEDLLESIQDYSQGGPDRFYFLEAYN
SKTKNFEDPPNHARSPGNIKLPKLRTLDVFSGCGGLSEGFHQAGISETLW
AIEMWDPAAQAFRLNNPGTTVFTEDCNVLLKLVMAGEVTNSLGQRLPQKG
DVEMLCGGPPCQGFSGMNRFYSKFKNSLVVSFLSYCDYYRPRFFLLENVR
NFVSYRRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRRAIILAAA
PGEKLPLFPEPLHVFAPRACQLSVVVDDKKFVSNITRLSSGPFRTITVRD
TMSDLPEIQNGASNSEIPYNGEPLSWFQRQLRGSHYQPILRDHICKDMSP
LVAARMRHIPLFPGSDWRDLPNIQVRLGDGVIAHKLQYTFHDVKNGYSST
GALRGVCSCAEGKACDPESRQFSTLIPWCLPHTGNRHNHWAGLYGRLEWD
GFFSTTVTNPEPMGKQGRVLHPEQHRVVSVRECARSQGFPDSYRFFGNIL
DRHRQVGNAVPPPLAKAIGLEIKLCLLS

3D structure

PDB

6w8w DNMT1 activity, base flipping mechanism and genome-wide DNA methylation are regulated by the DNA sequence context

Chain

Resolution

3.0 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	C1229 E1269 R1313 R1315
Catalytic site (residue number reindexed from 1)	C461 E497 R541 R543
Enzyme Commision number	2.1.1.37: DNA (cytosine-5-)-methyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	G1234 M1235 N1236 R1237 S1276 Q1343 R1427 R1492 C1501 H1504 R1508 H1509 W1512 M1535 K1537	G466 M467 N468 R469 S504 Q571 R655 R720 C729 H732 R736 H737 W740 M763 K765
BS02	dna	A	Y983 K985 G1226 P1227 P1228 C1229 Q1230 S1233 M1235 N1236 E1269 V1271 R1313 R1314 R1315 N1510 T1527 T1530 K1537	Y240 K242 G458 P459 P460 C461 Q462 S465 M467 N468 E497 V499 R541 R542 R543 N738 T755 T758 K765
BS03	SAH	A	F1148 S1149 G1150 L1154 E1171 M1172 G1226 N1580 A1581 V1582	F380 S381 G382 L386 E403 M404 G458 N808 A809 V810
BS04	ZN	A	C1479 C1481 H1504	C707 C709 H732
BS05	ZN	A	H796 C823	H65 C92

Gene Ontology

	Molecular Function
GO:0003682	chromatin binding
GO:0008168	methyltransferase activity

View graph for
Molecular Function

External links

PDB	RCSB:6w8w, PDBe:6w8w, PDBj:6w8w
PDBsum	6w8w
PubMed
UniProt	P13864\|DNMT1_MOUSE DNA (cytosine-5)-methyltransferase 1 (Gene Name=Dnmt1)

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