Structure of PDB 6w8l Chain A

Receptor sequence
>6w8lA (length=280) Species: 9606 (Homo sapiens) [Search protein sequence]
PTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKNHIAD
LKKEIEILRNLYHENIVKYKGICTENGIKLIMEFLPSGSLKEYLPKNKNK
INLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGL
TKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHEL
LTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEV
YQLMRKCWEFQPSNRTSFQNLIEGFEALLK
3D structure
PDB6w8l Design and optimization of a series of 4-(3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-2-amines: Dual inhibitors of TYK2 and JAK1.
ChainA
Resolution2.11 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1003 A1005 R1007 N1008 D1021
Catalytic site (residue number reindexed from 1) D129 A131 R133 N134 D147
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 R4S A L881 G882 E883 G884 V889 A906 F958 L959 G962 E966 L1010 D1021 L15 G16 E17 G18 V23 A40 F84 L85 G88 E92 L136 D147 MOAD: ic50=774nM
BindingDB: IC50=774nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6w8l, PDBe:6w8l, PDBj:6w8l
PDBsum6w8l
PubMed32253095
UniProtP23458|JAK1_HUMAN Tyrosine-protein kinase JAK1 (Gene Name=JAK1)

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