Structure of PDB 6w7g Chain A

Receptor sequence
>6w7gA (length=359) Species: 9606 (Homo sapiens) [Search protein sequence]
SFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQG
EIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM
QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFG
GVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDY
NPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVC
WKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSTDFWQKMLALG
NQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCD
DASIWRWDR
3D structure
PDB6w7g EEDi-5285: An Exceptionally Potent, Efficacious, and Orally Active Small-Molecule Inhibitor of Embryonic Ectoderm Development.
ChainA
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Q3A A F97 Y148 N194 K211 D310 Y365 M366 R367 F17 Y68 N114 K131 D230 Y285 M286 R287 MOAD: ic50=0.5nM
BindingDB: IC50=0.500000nM
BS02 Q3A A H199 R201 D202 L205 G248 I265 M271 I274 K275 Y278 H119 R121 D122 L125 G168 I185 M191 I194 K195 Y198 MOAD: ic50=0.5nM
BindingDB: IC50=0.500000nM
BS03 Q3A A G230 G231 K293 G150 G151 K213 MOAD: ic50=0.5nM
BindingDB: IC50=0.500000nM
External links
PDB RCSB:6w7g, PDBe:6w7g, PDBj:6w7g
PDBsum6w7g
PubMed32580550
UniProtO75530|EED_HUMAN Polycomb protein EED (Gene Name=EED)

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