Structure of PDB 6w5x Chain A

Receptor sequence

>6w5xA (length=427) Species: 9606 (Homo sapiens)

MATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAV
SYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVM
EIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGL
PQGPTVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIE
RETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKI
RSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGI
EHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKD
RNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKN
CNTSGIQTEWSPPLTMLFLCATKFSAS

3D structure

• PDB: 6w5x Crystal structure of human polymerase eta complexed with N7-benzylguanine and dCTP*
• Chain: A
• Resolution: 2.59 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	Q38 Y39 W42 G46 I47 I48 S62 W64 K86 K311 R313 P316 K317 T318 G320 S322 K323 N324 P326 T329	Q38 Y39 W42 G46 I47 I48 S62 W64 K86 K306 R308 P311 K312 T313 G315 S317 K318 N319 P321 T324
BS02	dna	A	S113 D115 E116 K224 S257 G259 G260 K261 L262 R377 L381 R382	S113 D115 E116 K219 S252 G254 G255 K256 L257 R372 L376 R377
BS03	0KX	A	D13 M14 D15 C16 F17 F18 Y52 R55 R61 D115 K231	D13 M14 D15 C16 F17 F18 Y52 R55 R61 D115 K226
BS04	MN	A	D13 D115 E116	D13 D115 E116
BS05	MN	A	D13 M14 D115	D13 M14 D115

Gene Ontology

Molecular Function

• GO:0003684 damaged DNA binding

Biological Process

• GO:0006281 DNA repair

External links

• PDB: RCSB:6w5x, PDBe:6w5x, PDBj:6w5x
• PDBsum: 6w5x
• UniProt: Q9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)