Structure of PDB 6w5j Chain A

Receptor sequence
>6w5jA (length=170) Species: 524364 (Norovirus Hu/1968/US) [Search protein sequence]
HAPPTLWSRVTKFGSGWGFWVSPTVFITTTHVVPTGVKEFFGEPLSSIAI
HQAGEFTQFRFSKKMRPDLTGMVLEEGCPEGTVCSVLIKRDSGELLPLAV
RMGAIASMRIQGRLVHGQSGMLLAKGMDLGTIPGDCGAPYVHKRGNDWVV
CGVHAAATKSGNTVVCAVQA
3D structure
PDB6w5j Structure-Guided Optimization of Dipeptidyl Inhibitors of Norovirus 3CL Protease.
ChainA
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.66: calicivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TKS A H30 I109 Q110 T134 C139 A158 A159 A160 H31 I110 Q111 T131 C136 A155 A156 A157
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6w5j, PDBe:6w5j, PDBj:6w5j
PDBsum6w5j
PubMed32945669
UniProtQ83883|POLG_NVN68 Genome polyprotein (Gene Name=ORF1)

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